Clinical trials play a prominent role today in medicine, but are not without controversy. These issues start from the day physicians begin their specialization process in medical school and continues onto their day-to-day practice as attendings with referral patterns and resulting financial incentives. This combined with the lack of training in basic issues of epistemology and statistics, allows poor interpretations of clinical trials to reign free. A proposal to integrate the notion of severity to help remedy these issues are made (...) by ensuring that studies are tested “As Severe As Reasonably Possible” will put P-values, multiplicity adjustments, and model checking in their rightful place. In light of this, multiple clinical trials are examined with an in-depth analysis of erroneous statistical inferences taken from phase III randomized trials, non-inferiority, early phase, as well as observational studies. Severe testing in the setting of medicine will help with alleviate some of the issues with the current misinterpretation of clinical studies. (shrink)

John Lavery's The First Wounded, London Hospital, August 1914 records a memorable event in the First World War. This painting and the archives of the Royal London Hospital provide a fascinating insight into the nursing and medical care of these early war casualties.

This paper investigates a well-known case of simultaneous discovery in twentieth-century chemistry, the origins of the concept of hybridisation, in the light of Kuhn's insights. There has been no ambiguity as to who discovered this concept, when it was "rst in print, and how important it was. The full-#edged form of the concept was published in 1931 independently by two American scientists John C. Slater (1900}1976) and Linus Pauling (1901}1994), although both of them had made their ideas public earlier: (...) Slater at the American Physical Society meetings in 1930, and Pauling in the Proceedings of the National Academy of Sciences in 1928. Slater and Pauling both argued for the necessity of using an s orbital as well as three p orbitals in the carbon atom in order to explain carbon's four valences and the tetrahedral structure of methane. The metaphor &hybridisation' for denoting this mix of s and p orbitals was "rst used by Robert S. Mulliken and J. H. Van Vleck before gaining currency with the scienti"c community around 1935.2 The concept of hybridisation was indeed indispensable for extending the quantum-mechanical interpretation of the chemical bond as an electron pairing from diatomic molecules to polyatomic ones. To be sure, the emergence of hybridisation attests to scientists' growing interest in exploring the borderland between physics and chemistry, a trend that led to the creation of physical chemistry in the late nineteenth century and of chemical physics and quantum chemistry in the 1920s and 30s. Slater and Pauling themselves experienced and on many occasions talked about the fruitfulness of interdisciplinary research; and historians have legitimately illuminated their works by examining them in this broad context.3 Yet the careful analysis of their research notes and published papers reveals that Slater and Pauling were working in quite disparate disciplinary traditions, with di!erent approaches, for di!erent audiences, and towards di!erent goals. The aim of this paper is to explore their di!erent routes to a common destination*hybridisation*and thereby to explicate tensions existing between physics and chemistry amidst the institutional and conceptual overlapping of the two disciplines. (shrink)

In response to the COVID-19 pandemic, Korean society has sought to vaccinate most of its population. Consequently, the Korean government has attempted to make vaccination compulsory by promoting awareness of its benefits. The administration has pushed for mandatory vaccination by claiming that vaccination is more beneficial than harmful, based on a utilitarian view. However, this view is difficult to justify based on the two levels of utilitarianism presented by R. M. Hare. Compulsory vaccination cannot satisfy the universalizability, nor the satisfaction (...) of preference, and exposes the difficulties of utilitarianism. In addition, mandatory vaccination is difficult to justify based on the perspective of fairness theory, that is, “justice as the fairness” of John Rawls and H. L. A. Hart’s principle of fairness. From the point of view of Hare’s utilitarianism and fairness theory, it has been shown that mandatory vaccination is not easily justified. In reality, the power of the state continues to strengthen, and we should examine this situation from a critical point of view. (shrink)

This book explores how and when biology emerged as a science in Germany. Beginning with the debate about organism between Georg Ernst Stahl and Gottfried Leibniz at the start of the eighteenth century, John Zammito traces the development of a new research program, culminating in 1800, in the formulation of developmental morphology. He shows how over the course of the century, naturalists undertook to transform some domains of natural history into a distinct branch of natural philosophy, which attempted not (...) only to describe but to explain the natural world and became, ultimately, the science of biology. (shrink)

The two theories that revolutionized physics in the twentieth century, relativity and quantum mechanics, are full of predictions that defy common sense. Recently, we used three such paradoxical ideas to prove “The Free Will Theorem” (strengthened here), which is the culmination of a series of theorems about quantum mechanics that began in the 1960s. It asserts, roughly, that if indeed we humans have free will, then elementary particles already have their own small share of this valuable commodity. More precisely, if (...) the experimenter can freely choose the directions in which to orient his apparatus in a certain measurement, then the particle’s response (to be pedantic—the universe’s response near the particle) is not determined by the entire previous history of the universe. Our argument combines the well-known consequence of relativity theory, that the time order of space-like separated events is not absolute, with the EPR paradox discovered by Einstein, Podolsky, and Rosen in 1935, and the Kochen-Specker Paradox of 1967 (See [2].) We follow Bohm in using a spin version of EPR and Peres in using his set of 33 directions, rather than the original configuration used by Kochen and Specker. More contentiously, the argument also involves the notion of free will, but we postpone further discussion of this to the last section of the article. Note that our proof does not mention “probabilities” or the “states” that determine them, which is.. (shrink)

Most scholars think not. But in this pioneering book, John H. Zammito challenges that view by revealing a precritical Kant who was immensely more influential than the one philosophers think they know.

In this philosophically sophisticated and historically significant work, John H. Zammito reconstructs Kant's composition of The Critique of Judgment and reveals that it underwent three major transformations before publication. He shows that Kant not only made his "cognitive" turn, expanding the project from a "Critique of Taste" to a Critique of Judgment but he also made an "ethical" turn. This "ethical" turn was provoked by controversies in German philosophical and religious culture, in particular the writings of Johann Herder and (...) the Sturm und Drang movement in art and science, as well as the related pantheism controversy. Such topicality made the Third Critique pivotal in creating a "Kantian" movement in the 1790s, leading directly to German Idealism and Romanticism. The austerity and grandeur of Kant's philosophical writings sometimes make it hard to recognize them as the products of a historical individual situated in the particular constellation of his time and society. Here Kant emerges as a concrete historical figure struggling to preserve the achievements of cosmopolitan Aufkl-rung against challenges in natural science, religion, and politics in the late 1780s. More specifically Zammito suggests that Kant's Third Critique was animated throughout by a fierce personal rivalry with Herder and by a strong commitment to traditional Christian ideas of God and human moral freedom. "A work of extraordinary erudition. Zammito's study is both comprehensive and novel, connecting Kant's work with the aesthetic and religious controversies of the late eighteenth century. He seems to have read everything. I know of no comparable historical study of Kant's Third Critique."-Arnulf Zweig, translator and editor of Kant's ;IPhilosophical Correspondence, 1759-1799;X "An intricate, subtle, and exciting explanation of how Kant's thinking developed and adjusted to new challenges over the decade from the first edition of the Critique of Pure Reason to the appearance of the Critique of Judgment. "--John W. Burbidge, Review of Metaphysics "There has been for a long time a serious gap in English commentary on Kant's Critique of Judgment Zammito's book finally fills it. All students and scholars of Kant will want to consult it."--Frederick Beiser, Times Literary Supplement. (shrink)

Includes bibliographical references and index. isbn 0-226-97861-3 (alk. paper) — isbn 0-226-97862-1 (pbk. : alk. paper) 1. Science — Philosophy. 2. Science — History. 3. Progress. I. Title. Q175 .Z25 2004 501 — dc2i 200301 1970 ...

This book is a study of comparative philosophy and theology. The themes are the critical issues arising from the modern interpretation of Confucian doctrine as they confront the Christian beliefs of the nineteenth and twentieth centuries.

Kant’s philosophy of science takes on sharp contour in terms of his interaction with the practicing life scientists of his day, particularly Johann Blumenbach and the latter’s student, Christoph Girtanner, who in 1796 attempted to synthesize the ideas of Kant and Blumenbach. Indeed, Kant’s engagement with the life sciences played a far more substantial role in his transcendental philosophy than has been recognized hitherto. The theory of epigenesis, especially in light of Kant’s famous analogy in the first Critique, posed crucial (...) questions regarding the ‘looseness of fit’ between the constitutive and the regulative in Kant’s theory of empirical law. A detailed examination of Kant’s struggle with epigenesis between 1784 and 1790 demonstrates his grave reservations about its hylozoist implications, leading to his even stronger insistence on the discrimination of constitutive from regulative uses of reason. The continuing relevance of these issues for Kant’s philosophy of science is clear from the work of Buchdahl and its contemporary reception. (shrink)

From its beginnings, Confucianism has vibrantly taught that each person is able to find the Way individually in service to the community and the world. For over 2,600 years, Confucianism has sustained a continual process of transformation and growth. In this comprehensive new work, John Berthrong examines the vitality and expansion of the Confucian tradition throughout East Asia and into the entire modern world.Confucianism has been credited with being the dominant social and intellectual force shaping the enduring civilizations of (...) East Asia. If we are to grasp the history of East Asia, we must understand the role that Confucianism has played in the social and cultural formation of the entire region. Just as civilizations are ever-changing, there has been nothing timeless or static about Confucianism.Berthrong’s study is unique in its discussion of each of the historical and regional phases of the development of the Confucian Tao. All too often, Confucian studies have focused exclusively on the classical early period and the great thinkers of the later neo-Confucian revival in the Sung Ming dynasties. Berthrong’s work opens the reader’s eyes to the often neglected gifts of scholars of the Han, T’ang, and the modern periods, as well as to the vast contributions of Korea and Japan. The author concludes this revelatory study with an examination of the contemporary renewal of the Confucian Way in East Asia and its recent spread to the West. (shrink)

A cross-cultural comparsion of creativity that introduces Neo-Confucian discourse as a sophisticated dialogue partner with modern western speculative philosophy and theology.

A veritable tidal shift in Herder scholarship has taken place over the last quarter century, primarily but not exclusively in German. This review essay seeks to evoke the richness and vitality of this revival with the hope of persuading American academics that some ill-founded opinions still circulating concerning Herder's "irrationalism" and chauvinistic, even racist nationalism, and his philosophical naivety and literary effrontery, might at last be put to rest. The recent revival has brough sharply to the fore two crucial aspects (...) of Herder. First, there is the contribution of Herder's thought to the emergent cultural and social sciences. Second, for Herder the "science of man" was also a natural science: the division between the humanities and the natural sciences that has been such a hallmark of the age from Kant until very recently did not exist for Herder. (shrink)

Although best known as a scientific instrument maker, John Rowley extended his sphere of activity very considerably as Master of Mechanics to George I and as a hydraulic engineer at the Offices of Ordnance and Works. Re-examined and untapped sources provide fresh evidence of these aspects of his work and highlight his predilection for the arts and the virtuosity of his artefacts. The findings also have implications for studies of the instrument-making trade in the early eighteenth century.

ABSTRACTRheinberger's brief history brings into sharp profile the importance of history of science for a philosophical understanding of historical practice. Rheinberger presents thought about the nature of science by leading scientists and their interpreters over the course of the twentieth century as emphasizing increasingly the local and developmental character of their learning practices, thus making the conception of knowledge dependent upon historical experience, “historicizing epistemology.” Linking his account of thought about science to his own work on “experimental systems,” I draw (...) extensive parallels with other work in the local history of science and consider the epistemological implications both for the relation between history and philosophy of science and between history and theory more broadly. In doing so, I suggest that the long‐standing gap between the natural sciences and history as a “human science” has been significantly bridged by the insistence upon the local, mediated, indeed “historicized epistemology” of actual science. (shrink)

Reconstructions of Kant are prominent in the contemporary debate over naturalism. Given that this naturalism rejects a priori principles, Kant's anti-naturalism can best be discerned in the “critical turn” as a response to David Hume. Hume did not awaken Kant to criticize but to defend rational metaphysics. But when Kant went transcendental did he not, in fact, go transcendent? The controversy in the 1990s over John McDowell's Mind and World explored just this suspicion: the questions of the normative force (...) of reason and of the ontological “space of reasons” vis- -vis the world. “Bald naturalism” appears to “extrude” rationality both ontologically and epistemologically from the natural world. Kant sought to discriminate a transcendental middle ground, safe from either extrusion. But was Kant's notion of the autonomy and spontaneity of reason as metaphysically innocent as McDowell's critics would have it? Situating Hume and naturalism in the eighteenth-century German context can help us understand the “critical turn” more accurately. While Hume recognized procedural proprieties for reflection, he did not believe in their a priori necessity. Initially, Kant shared that view. What assimilating Leibniz and Locke in the late 1760s garnered for Kant—the simultaneous spontaneity and self-transparency of reason—seemed to provide a means for overcoming Hume's skepticism and establishing a new foundation for metaphysics. Accordingly, all of the efforts of modern Kantianism notwithstanding, there is more than a whiff of the transcendent in Kant's transcendentalism. (shrink)

_Brings Chinese Daoist and Confucian thought into conversation with Western process, pragmatic, and naturalist philosophy and theology._.

Margery Kempe and her Book studied in both literary and historical context.

Exploring the relationship between morality and professional ideals, Kultgen examines the structure and organization of occupations and the ideals and ideology associated with professions. He argues that professionalization of occupations can both harm and benefit society, and that by converting occupations into organized special interest groups, the professions serve some sectors of society at the expense of others. On the other hand, he highlights the positive points of the professional ideal and explores ways in which it can be used to (...) advance the physical and moral welfare of society. Kultgen also shows how it is the practices within the professions that determine whether rules and ideals are used as masks for self-interest or for genuinely moral purposes. ISBN 0-8122-8094-6: $14.95. (shrink)

Exploring the relationship between morality and professional ideals, Kultgen examines the structure and organization of occupations and the ideals and ideology associated with professions. He argues that professionalization of occupations can both harm and benefit society, and that by converting occupations into organized special interest groups, the professions serve some sectors of society at the expense of others. On the other hand, he highlights the positive points of the professional ideal and explores ways in which it can be used to (...) advance the physical and moral welfare of society. Kultgen also shows how it is the practices within the professions that determine whether rules and ideals are used as masks for self-interest or for genuinely moral purposes. ISBN 0-8122-8094-6: $14.95. (shrink)

While functioning quite well for many years, the bioethics profession is in crisis. John H. Evans closely examines the history of the bioethics profession, and based on the sociological reasons the profession evolved as it did, proposes a radical solution to the crisis.

The ontology of ‘powerful qualities’ is gaining an increasing amount of attention in the literature on properties. This is the view that the so-called categorical or qualitative properties are identical with ‘dispositional’ properties. The position is associated with C.B. Martin, John Heil, Galen Strawson and Jonathan Jacobs. Robert Schroer ( 2012 ) has recently mounted a number of criticisms against the powerful qualities view as conceived by these main adherents, and has also advanced his own (radically different) version of (...) the view. In this paper I have three main aims: firstly, I shall defend the ontology from his critique, arguing that his criticisms do not damage the position. Secondly, I shall argue that Schroer’s own version of the view is untenable. Thirdly, the paper shall serve to clear up some conceptual confusions that often bedevil the powerful qualities view. (shrink)

The ontology of ‘powerful qualities’ is gaining an increasing amount of attention in the literature on properties. This is the view that the so-called categorical or qualitative properties are identical with ‘dispositional’ properties. The position is associated with C.B. Martin, John Heil, Galen Strawson and Jonathan Jacobs. Robert Schroer ( 2012 ) has recently mounted a number of criticisms against the powerful qualities view as conceived by these main adherents, and has also advanced his own (radically different) version of (...) the view. In this paper I have three main aims: firstly, I shall defend the ontology from his critique, arguing that his criticisms do not damage the position. Secondly, I shall argue that Schroer’s own version of the view is untenable. Thirdly, the paper shall serve to clear up some conceptual confusions that often bedevil the powerful qualities view. (shrink)

The conflict between Kant and the medical faculty was far more complex and substantial than is indicated in the section of his famous Conflict of the Faculties addressing this matter. In this essay I will consider not only what Kant, as a philoso­pher, thought of medicine as a faculty, but what medicine as a faculty thought of Kant as a philosopher.

The conflict between Kant and the medical faculty was far more complex and substantial than is indicated in the section of his famous Conflict of the Faculties addressing this matter. In this essay I will consider not only what Kant, as a philoso­pher, thought of medicine as a faculty, but what medicine as a faculty thought of Kant as a philosopher.

Has the emergence of post-positivism in philosophy of science changed the terms of the “is/ought” dichotomy? If it has demonstrated convincingly that there are no “facts” apart from the theoretical frames and evaluative standards constructing them, can such a cordon sanitaire really be upheld between “facts” and values? The point I wish to stress is that philosophy of science has had a central role in constituting and imposing the fact/value dichotomy and a revolution in the philosophy of science should not (...) leave the dichotomy unaffected. The connection between post-positivism and naturalism will be my guiding thread in considering this “last dogma of positivism.” First this essay will specify the sense of naturalism that it will take to be essential to the post-positivist philosophy of science: the deflation of the notion of the “purity” of scientific knowledge. Then it will turn to the question of the implications that follow for the “autonomy” of ethics, including the danger posed by a new form of scientistic reductionism. (shrink)

Brings Chinese Daoist and Confucian thought into conversation with Western process, pragmatic, and naturalist philosophy and theology.

Bioethicists’ attraction to principlism is rooted in a Western view of how matters that affect the public ought to be deliberated and decided: their resolution ought to be so structured and constrained that it can be understood and verified even by those at a remove from the circumstances of the problem. That view of deliberation, itself fostered by the Western view of government, has encouraged principlism to spread from its source in human subjects research into other areas of bioethics discourse.

Ankersmit's articulation of a postmodern theory of history takes seriously both the strengths of traditional historicism and the right of historians to decide what makes sense for disciplinary practice. That makes him an exemplary interlocutor. Ankersmit proposes a theory of historical "representation" which radicalizes the narrative approach to historiography along the lines of poststructuralist textualism. Against this postmodernism but invoking some of his own arguments, I defend the traditional historicist position. I formulate criticisms of the theory of reference entailed in (...) his notion of "narrative substance," of his master analogy of historiography with modern painting, and finally of his characterization of historical hermeneutics. In each case I find him guilty of the hyperbole which he himself cautions against. While it is true that historical narratives cannot be taken to be transparent, in taking them to be opaque Ankersmit puts himself in an untenable position. Finally, Ankersmit seeks to buttress his theoretical case by an interpretation of the new cultural historical texts of authors like Davis and Ginzburg. While this is a concreteness heartily to be welcomed in philosophers of history, I cannot find his construction of this new school's work plausible. (shrink)